The Role of Nuclear Position and Locus Conformation in Regulating V(D)J Recombination of the Tcrb Locus
نویسنده
چکیده
The Role of Nuclear Position and Locus Conformation in Regulating V(D)J Recombination of the Tcrb Locus by Ryan Jon Schlimgen Department of Immunology Duke University Date:_______________________ Approved: ___________________________ Dr. Michael S. Krangel, Supervisor ___________________________ Dr. Yuan Zhuang, Chair ___________________________ Dr. Garnett Kelsoe ___________________________ Dr. You-Wen He ___________________________ Dr. Tannishtha Reya An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Immunology in the Graduate School of Duke University 2008 Copyright by Ryan Jon Schlimgen 2008
منابع مشابه
Control of antigen receptor diversity through spatial regulation of V(D)J recombination.
Lymphocytes recognize a vast variety of pathogens by expressing a diverse repertoire of antigen receptor genes that are assembled by V(D)J recombination in immature B cells (Igh, Igk) and T cells (Tcrb, Tcra/d). V(D)J recombination takes place in the 3' proximal domain containing the D, J, and C gene segments, whereas 31 (Tcrb) to 200 (Igh) V genes are spread over a large region of 0.67 (Tcrb) ...
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